About Crystalys Therapeutics

our mission

Crystalys Therapeutics’ mission is to address the significant unmet medical needs of people living with gout. Guided by a focused commitment to scientific innovation and a passion for improving patient care, we develop targeted therapies to better control uric acid, reduce flares, resolve tophi and help prevent long-term joint damage.

With agility, diligence, and compassion, we strive to deliver meaningful, lasting improvements in patient outcomes.

about us

Crystalys Therapeutics is a clinical-stage biopharmaceutical company focused on advancing innovative therapies to address the significant unmet medical needs of patients living with gout.

Gout is a chronic metabolic disease driven by elevated levels of uric acid in the bloodstream. When uric acid accumulates, monosodium urate crystals can form and deposit in joints and tissues, leading to painful inflammatory flares and long-term joint damage. Despite the availability of currently approved treatments, many patients continue to struggle with inadequate uric acid control and ongoing disease burden and are in need of additional treatment options.

Crystalys is committed to developing therapies designed to improve uric acid management and help patients achieve and maintain healthy serum urate levels. The company’s lead investigational therapy, dotinurad, is a next-generation, highly selective urate transporter 1 (URAT1) inhibitor designed to reduce serum uric acid by targeting the renal transport pathways responsible for urate reabsorption.

Crystalys Therapeutics is headquartered in San Diego, California, and was co-founded by the Executive Team, Catalys Pacific, and Novo Holdings.

our values

Passionnoun | pa-shən

: a strong feeling of enthusiasm or excitement for something or about doing

Focusnoun | fō-kəs

: a center of activity, attraction, or attention

Agilitynoun | ə-ˈji-lə-tē

: the power of moving quickly and easily; nimbleness

Diligencenoun | di-lə-jən(t)s

: steady, earnest, and energetic effort : devoted and painstaking work and application to accomplish an undertaking

Compassionnoun | kəm-ˈpa-shən

: sympathetic consciousness of others’ distress together with a desire to alleviate it

management team

James Mackay, Ph.D.

President & Chief Executive Officer

Justin Thacker, CPA

Chief Financial Officer

Nihar Bhakta, M.D.

Chief Medical Officer

Ashwin Ram, M.D.

Chief Operating Officer

DeAnne Reid

Executive Director, Operations & Business Development

board of directors

BT Slingsby, M.D., Ph.D.

Catalys Pacific

Kenneth Harrison, Ph.D.

Novo Holdings

Chris Garabedian

Perceptive Advisors, Xontogeny

David Jin

Fortress Bio

James Mackay, Ph.D.

President & Chief Executive Officer

Tim Walbert

Independent Board Director

Crystalys Therapeutics’ mission is to address the significant unmet medical needs of people living with gout.

Through our passionate pursuit of excellence in medicine, we are dedicated to developing new therapeutics and helping improve the lives of patients.